Photocatalysis – The Doyle Group

101. Light-Promoted C(sp³)–C(sp³) Reductive Elimination from Dialkyl Ni(II) Complexes

"Light-Promoted C(sp³)–C(sp³) Reductive Elimination from Dialkyl Ni(II) Complexes" Cusumano, A. Q.; Chaffin, B. C.; Cagan, D. A.; DiLuzio, S.; Sutcliffe, E.; Hadt, R. G.; Doyle, A. G. J. Am. Chem. Soc., 2025, ASAP. [DOI: 10.1021/jacs.5c09925] Link PDF

101. Light-Promoted C(sp³)–C(sp³) Reductive Elimination from Dialkyl Ni(II) ComplexesFlora Fan2025-09-08T08:58:50-07:00

97. Applying Active Learning toward Building a Generalizable Model for Ni-Photoredox Cross-Electrophile Coupling of Aryl and Alkyl Bromides

"Applying Active Learning toward Building a Generalizable Model for Ni-Photoredox Cross-Electrophile Coupling of Aryl and Alkyl Bromides" Souza, L. W.; Ricke, N. D.; Chaffin, B. C.; Fortunato, M. E.; Jiang, S.; Soylu, C.; Caya, T. C.; Lau, S. H.; Wieser, K. A.; Doyle, A. G.; Tan, K. L. J. Am. Chem. Soc., 2025, 147, 18747-18759.

97. Applying Active Learning toward Building a Generalizable Model for Ni-Photoredox Cross-Electrophile Coupling of Aryl and Alkyl BromidesFlora Fan2025-07-03T17:23:09-07:00

95. Diversification of acridinium photocatalysts: Property tuning and reactivity in model reactions

"Diversification of acridinium photocatalysts: Property tuning and reactivity in model reactions" Wang, J. Y.; Fan, F.; Ruos, M. E.; Adao Gomes, L.; Lavin, M.; O'Connor, T. J.; Lopez, S. A.; Doyle, A. G. Tet. Lett., 2025, 160, 155546. [DOI: 10.1016/j.tetlet.2025.155546] Link PDF

95. Diversification of acridinium photocatalysts: Property tuning and reactivity in model reactionsFlora Fan2025-07-03T17:19:04-07:00

92. Cooperative Phosphine-Photoredox Catalysis Enables N–H Activation of Azoles for Intermolecular Olefin Hydroamination

"Cooperative Phosphine-Photoredox Catalysis Enables N–H Activation of Azoles for Intermolecular Olefin Hydroamination" Sedillo, K.; Fan, F.; Knowles, R. R.; Doyle, A. G. J. Am. Chem. Soc., 2024, 146, 20349-20356. [DOI: 10.1021/jacs.4c05881] Link PDF

92. Cooperative Phosphine-Photoredox Catalysis Enables N–H Activation of Azoles for Intermolecular Olefin HydroaminationFlora Fan2024-08-06T13:50:52-07:00

82. A General Photocatalytic Strategy for Nucleophilic Amination of Primary and Secondary Benzylic C–H Bonds

"A General Photocatalytic Strategy for Nucleophilic Amination of Primary and Secondary Benzylic C–H Bonds" Ruos, M. E.; Kinney, R. G.; Ring, O. T.; Doyle, A. G. J. Am. Chem. Soc. 2023, 145, 18487-18496. [DOI: 10.1021/jacs.3c04912] Link PDF

82. A General Photocatalytic Strategy for Nucleophilic Amination of Primary and Secondary Benzylic C–H BondsFlora Fan2024-05-27T18:31:32-07:00

75. Radical Redox Annulations: A General Light-Driven Method for the Synthesis of Saturated Heterocycles

Murray, P. R. D.; Leibler, I. N.-M.; Hell, S. M.; Villalona, E.; Doyle, A. G.; Knowles, R. R. ACS Catal. 2022, 12, 13732-13740. [DOI: 10.1021/acscatal.2c04316] Link PDF

75. Radical Redox Annulations: A General Light-Driven Method for the Synthesis of Saturated HeterocyclesWill Lau2022-12-30T17:39:02-08:00

73. Ni/Photoredox-Catalyzed C(sp3)–C(sp3) Coupling between Aziridines and Acetals as Alcohol-Derived Alkyl Radical Precursors

Dongbang, S; Doyle, A. G. J. Am. Chem. Soc. 2022, 144, 20067–20077. [DOI: 10.1021/jacs.2c09294] Link PDF

73. Ni/Photoredox-Catalyzed C(sp3)–C(sp3) Coupling between Aziridines and Acetals as Alcohol-Derived Alkyl Radical PrecursorsWill Lau2022-12-30T17:42:21-08:00

71. Bioinspired Supercharging of Photoredox Catalysis for Applications in Energy and Chemical Manufacturing

Millet, A.; Cesana, P. T.; Sedillo, K.; Bird, M. J.; Schlau-Cohen, G. S.; Doyle, A. G.; MacMillan, D. W. C.; Scholes, G. D. Acc. Chem. Res. 2022, 55, 1423-1434. [DOI: 10.1021/acs.accounts.2c00083] Link PDF

71. Bioinspired Supercharging of Photoredox Catalysis for Applications in Energy and Chemical ManufacturingWill Lau2022-12-30T17:27:44-08:00

68. Using Data Science to Guide Aryl Bromide Substrate Scope Analysis in a Ni/Photoredox-Catalyzed Cross-Coupling with Acetals as Alcohol-Derived Radical Sources

Kariofillis, S. K.; Jiang, S.; Żurański, A. M.; Gandhi, S. S.; Martinez Alvarado, J. I.; Doyle, A. G. J. Am. Chem. Soc. 2022, 144, 1045-1055. [DOI: 10.1021/jacs.1c12203] Link PDF

68. Using Data Science to Guide Aryl Bromide Substrate Scope Analysis in a Ni/Photoredox-Catalyzed Cross-Coupling with Acetals as Alcohol-Derived Radical SourcesWill Lau2022-12-30T17:04:00-08:00

67. A General Strategy for C(sp3)–H Functionalization with Nucleophiles Using Methyl Radical as a Hydrogen Atom Abstractor

Leibler, I. N.-M.; Tekle-Smith, M. A.; Doyle, A. G. Nat. Commun. 2021, 12, 6950. [DOI: 10.1038/s41467-021-27165-z] Link PDF

67. A General Strategy for C(sp3)–H Functionalization with Nucleophiles Using Methyl Radical as a Hydrogen Atom AbstractorWill Lau2022-12-30T17:01:58-08:00