Bayesian Reaction Optimization as a Tool for Chemical Synthesis
Ben, Marvin, and Jesus' work on Bayesian reaction optimization was recently published in Nature. Congratulations!
Synthetic and Mechanistic Implications of Chlorine Photoelimination in Nickel/Photoredox C(sp3)–H Cross-Coupling
Stavros’ review paper on chlorine photoelimination in Ni/photoredox C(sp3)–H cross-coupling was recently published in Acc. Chem. Res. Congratulations!
Nucleophilic (Radio)Fluorination of Redox-Active Esters via Radical-Polar Crossover Enabled by Photoredox Catalysis
Nucleophilic (Radio)Fluorination of Redox-Active Esters via Radical-Polar Crossover Enabled by Photoredox Catalysis. Eric and John’s work in collaboration with BMS on a redox-neutral method for nucleophilic fluorination of phthalimide esters was just published in JACS (check it out here)! Congrats on completing an exciting project!
Regioselective Cross-Electrophile Coupling of Epoxides and (Hetero)aryl Iodides via Ni/Ti/Photoredox Catalysis
Marvin’s work on developing a novel methodology for cross-coupling epoxides and aryl iodides using Ni/Ti/Photoredox catalysis was just published in ACS Catalysis! The mild cross-electrophile approach tolerates three distinct classes of epoxides and a broad scope of aryl iodides. Check it out here!
Role of Electron-Deficient Olefin Ligands in a Ni-Catalyzed Aziridine Cross-Coupling To Generate Quaternary Carbons
Jesús, Wendy, and Stephen’s work on elucidating the mechanism of Ni-catalyzed Negishi Couplings of Aziridines, and the associated ligand effects of electron deficient olefin ligand, Fro-DO, was just published in JACS! Congrats on the completion of an exciting project!
Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source
Stavros, Ben, and Makeda’s work, in collaboration with Mike Zacuto at Celgene, to “photo-eliminate a gap in the methylation methodology” has recently been published in JACS! Congrats to the team and great work!
Synthesis of β-Phenethylamines via Ni/Photoredox Cross-Electrophile Coupling of Aliphatic Aziridines and Aryl Iodides
Talia, Junyi, and Mani’s work on developing a new Ni/Photoredox methodology to synthesize pharmaceutically relevant β-Phenethylamines was recently accepted and published in JACS! Great work!
Triplet d-d Excited States of Ni(II) Complexes Relevant to Photoredox Catalysis
Congrats to Stephen on recently publishing a study on how Ni(II) intermediates proposed in photocatalytic cycles can interact with light and lead to Ni-C bond homolysis. This spectroscopic and organometallic mechanistic work in collaboration with the Scholes and Castellano labs is now available to read in JACS! Congrats all!
Direct Use of Carboxylic Acids in the Photocatalytic Hydroacylation of Styrenes to Generate Dialkyl Ketones
Jesus, Alyssa, Andrea, and Erin’s work on photocatalytic hydroacylation of styrenes was recently published in Org. Lett. (check it out here). Great work everyone!
Generation of Phosphoranyl Radicals via Photoredox Catalysis Enables Voltage-Independent Activation of Strong C-O Bonds
Erin and Alyssa’s paper on the deoxygenation of alcohols and carboxylic acids via phosphoranyl radical intermediates was just accepted by ACS Catalysis. Totally rad!
