Using Data Science to Guide Aryl Bromide Substrate Scope Analysis in a Ni/Photoredox-Catalyzed Cross-Coupling with Acetals as Alcohol-Derived Radical Sources
Stavros, Shutian, Andrzej, Shivanni, and Jesus’ paper on a Ni/photoredox-catalyzed (deutero)methylation and alkylation of aryl halides with integration of data science techniques to quantify population-wide reactivity trends was recently published in JACS. A great team effort!
Welcome New Doyle Lab Members!
We welcome to the lab four first years, Maddy, Erin, Judah, and Daniel! We’re happy to have you in the group and excited for all your future research endeavors.
A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor
Izzy and Makeda’ work on developing a sequential hydrogen atom transfer and oxidative radical-polar crossover strategy that transforms C(sp3)–H bonds into carbocations functionalized by a variety of nucleophiles was published in Nature Communications. Great work and congratulations!
A biohybrid strategy for enabling photoredox catalysis with low-energy light
Stephen and Jesus’ paper on developing a biohybrid photocatalyst to perform thiol-ene coupling and cysteinyl-desulfurization reactions was recently published in Chem. Congrats to the whole team!
The Evolution of Data-Driven Modeling in Organic Chemistry
Wendy's recent outlook article detailing the history and current state of the field of data-driven modeling in organic chemistry has been published in ACS Central Science. Congrats to Wendy and her collaborators in the Sigman and Anslyn labs on a
Phosphine/Photoredox Catalyzed Anti-Markovnikov Hydroamination of Olefins with Primary Sulfonamides via α-scission from Phosphoranyl Radicals
Kassandra and Alex's work using phosphine and photoredox catalysis to perform hydroamination of olefins via α-scission of phosphoranyl radicals was recently published in JACS. Nice work and congrats to all!
