A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor
Izzy and Makeda’ work on developing a sequential hydrogen atom transfer and oxidative radical-polar crossover strategy that transforms C(sp3)–H bonds into carbocations functionalized by a variety of nucleophiles was published in Nature Communications. Great work and congratulations!
A biohybrid strategy for enabling photoredox catalysis with low-energy light
Stephen and Jesus’ paper on developing a biohybrid photocatalyst to perform thiol-ene coupling and cysteinyl-desulfurization reactions was recently published in Chem. Congrats to the whole team!
The Evolution of Data-Driven Modeling in Organic Chemistry
Wendy's recent outlook article detailing the history and current state of the field of data-driven modeling in organic chemistry has been published in ACS Central Science. Congrats to Wendy and her collaborators in the Sigman and Anslyn labs on a
Phosphine/Photoredox Catalyzed Anti-Markovnikov Hydroamination of Olefins with Primary Sulfonamides via α-scission from Phosphoranyl Radicals
Kassandra and Alex's work using phosphine and photoredox catalysis to perform hydroamination of olefins via α-scission of phosphoranyl radicals was recently published in JACS. Nice work and congrats to all!
Univariate Classification of Phosphine Ligation State and Reactivity in Cross-Coupling Catalysis
Sam and Julia's recent work classifying phosphine ligation state in cross-coupling reactions on the basis of a conformer-specific buried volume parameter has been published in Science. Congratulations to the whole Doyle, Sigman, and Merck phosphine team!
ACS EJ Corey Award for Abby
Congratulations to Abby for winning the 2022 ACS EJ Corey Award for Outstanding Original Contribution in Organic Synthesis by a Young Investigator! Abby will be honored at the ACS Spring meeting in San Diego this upcoming March. A well deserved
